• c-src The transcription factor CREB has been extensively stu

  2021-03-23

  

  The transcription factor CREB has been extensively studied for its role in hippocampus-dependent learning and memory (West et al., 2002, Lonze and Ginty, 2002). Previous research has demonstrated that the phosphorylation of CREB at Ser133, performed by the ERK1/2 signaling pathway, initiates a casca

• The T cell receptor TCR pathway is

  2021-03-23

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• The Penicillium strain used in

  2021-03-23

  

  The Penicillium strain used in this work was isolated from Atlantic forest soil and previously screened as lipase producer (Tauk-Tornisielo et al., 2005). The immobilization was previously evaluated using hydrophobic supports, i.e. agarose based butyl-(But), phenyl-(Phe) and octyl-Sepharose (Oct), a

• The Wnt catenin signaling pathway

  2021-03-23

  

  The Wnt/β-catenin signaling pathway is a downstream target of SOX9 and is involved in a variety of cellular responses, including cell migration, proliferation, and differentiation [14]. Several studies have identified the Wnt/β-catenin signaling pathway as essential for cartilage function, and it is

• Several molecular differences between visceral and subcutane

  2021-03-23

  

  Several molecular differences between visceral and subcutaneous adipose tissue have been described. One of the most demarcating differences between adipose depots is the signature of developmental genes, including Hox, Shox, and T-box genes [12], [13]. Lineage tracing studies have revealed key devel

• Pifithrin-μ Neuronal cells have highly developed ER which ma

  2021-03-23

  

  Neuronal Pifithrin-μ have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-li

• The Inhibitor of APoptosis IAP proteins were first identifie

  2021-03-23

  

  The Inhibitor of APoptosis (IAP) proteins were first identified as gene products of baculovirus that inhibited apoptosis of infected insect NK 252 (Clem et al., 1991, Crook et al., 1993). Subsequently, the mammalian IAP family was identified (Rothe et al., 1995, Uren et al., 1996). All members of t

• Another pathway that requires proper DUB recruitment is the

  2021-03-23

  

  Another pathway that requires proper DUB recruitment is the DNA damage response (DDR). After ultraviolet (UV)-induced DNA damage, monoubiquitylated proliferating cell nuclear antigen (PCNA) mediates signaling that leads to repair. The DUB complex USP1/USP1-associated factor 1 (UAF1) deubiquitylates

• It was hypothesized that if modafinil

  2021-03-23

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• br Concluding remark br Acknowledgements br Detection and

  2021-03-23

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human flap inhibitor daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cancer

• A range of inhibitors were therefore synthesized

  2021-03-23

  

  A range of inhibitors were therefore synthesized containing either carboxylic Sulfo-NHS-SS-Biotin or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respectively (). A

• The co occurrence of the AA and the AA domains

  2021-03-23

  

  The co-occurrence of the AA12 and the AA8 domains in CcPDH would allow for electron transfer between these domains. Such electron transfer is known to occur in CDH, and the AA8 family in CAZy is in fact largely comprised of cytochrome domains of multi-domain CDHs. One notable exception concerns the

• Significantly less is known about regulation of phytocystati

  2021-03-23

  

  Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t

• Compounds and were outliers for this equation being

  2021-03-22

  

  Compounds and were outliers for this equation being the two most reactive compounds. The presence of outliers implies that other factors or specific mechanisms are involved in their chemical hydrolysis. Generally urea derivatives prove to be highly stable in aqueous solutions in vitro. Additionally

• The Fontan circulation When first described in

  2021-03-22

  

  The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital BMS 299897 sale disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a tota

14814 records 692/988 page Previous Next First page 上5页 691692693694695 下5页 Last page